2,4-Dinitrotoluene (2,4-DNT) administered orally was carcinogenic in rats producing liver, mammary and skin tumours, and was also active in mice producing kidney tumours. Binding to DNA occurred in rodents treated with 2,4-DNT by either the oral or intraperitoneal route, and other evidence of genotoxicity in rats treated orally has been recorded including chromosomal damage and unscheduled DNA synthesis. Mutagenic potential was reported in Ames bacterial tests. Dominant lethal studies in rodents treated orally or by injection provided no consistent indication that 2,4-DNT was able to induce mutations that are transmissible to the next generation. A reduced fertility has been seen in rats and mice treated orally. In repeated oral studies, 2,4-DNT produced principally testes or ovary damage, liver injury and effects on the blood and nervous system in rats, mice and dogs. 2,4-DNT was of a moderate acute oral toxicity in rodents. It was not irritating to the eye and skin of laboratory animals.

In man, exposure to dinitrotoluene, primarily the 2,4-isomer, induced anaemia and other blood effects, as well as jaundice and neurological disorders. It was also associated with a slightly higher than expected number of cancers of the liver and bile duct. An indication of an increased death rate from heart disease was noted in workers heavily exposed to 2,4-DNT. Skin sensitization to dinitrotoluene has been reported following occupational exposure. There was no convincing evidence of any effect on sperm counts and fertility.

Date of Publication: 1994

Number of Pages: 10

CAS Number*: 121-14-2

25321-14-6

Format: PDF available for immediate download

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