Chlorophyll occurs naturally in the diet of man; it is present in green plants. Orally administered chlorophyll and potassium sodium copper chlorophyllin have a long history of therapeutic use in man. Chlorophyll may cause photosensitization reactions when in contact with human skin, and ingestion of a mixture of chlorophyll and related compounds may have exacerbated a pre-existing skin condition.

In mice, chlorophyllin and one of its copper complexes were of low acute oral toxicity, and single injections of chlorophyllin caused effects on the nervous system. Repeated oral administration of potassium disodium copper chlorophyllin caused mild effects on the blood of rats while potassium sodium chlorophyllin produced slight increases in the weights of various organs. In limited feeding studies with copper chlorophyllin complexes (the potassium sodium and potassium disodium derivatives) there were no effects on fertility or the number of offspring produced by rats, but the growth and viability of the offspring were reduced and slight muscular degeneration was found at weaning. A limited oral study with potassium sodium copper chlorophyllin gave no evidence of carcinogenicity in rats. Copper chlorophyll and sodium copper chlorophyllin were inactive in Ames mutagenicity tests in bacteria, and no convincing evidence of mutagenicity was demonstrated with copper chlorophyllin in the bacterium Escherichia coli. Chlorophyll, copper chlorophyll and sodium copper chlorophyllin did not damage the chromosomes of hamster cells in culture. No mutagenic activity was seen in a fruit fly assay using chlorophyll and sodium copper chlorophyllin.

Date of Publication: 1991

Number of Pages: 7

CAS Number*: 1406-65-1














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