In studies involving repeated oral administration of hydrogen cyanamide to rodents, cellular degeneration in the testes and tissue changes in the ovaries, urinary bladder, kidneys and liver were reported, whereas calcium cyanamide formulations produced tissue abnormalities in the liver, bile duct, thyroid, pituitary, adrenals, spleen and male reproductive system (resulting in decreased sperm production). Fertility was reduced and embryo survival decreased in rats given repeated oral doses of hydrogen cyanamide. Oral carcinogenicity studies with hydrogen cyanamide or a calcium cyanamide formulation in rats or mice gave equivocal findings. Calcium cyanamide was weakly mutagenic in an Ames bacterial assay and was genotoxic to yeast. Hydrogen cyanamide gave no evidence of activity in a range of genotoxicity screening assays.
Date of Publication: 1993
Number of Pages: 11
CAS Number*: 420-04-2
156-62-7
8013-88-5
17292-62-5
Format: PDF available for immediate download
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