Changes in blood cell production, effects on a number of organs including the gastro-intestinal tract, kidney, liver and heart and pigment changes of the fur were seen in studies in a variety of laboratory animals involving the oral, skin or injection routes. Some evidence of impairment of female reproduction has been seen in limited studies in rats receiving hydroquinone in the diet. Subcutaneous injections of hydroquinone reduced the fertility of male rats and damaged the reproductive organs. Carcinogenicity has been reported in oral studies in rats and mice. Chromosomal damage was induced in mice given hydroquinone by injection or orally. A number of other mutagenicity studies in intact animals gave negative results. Chromosomal effects and point mutations have been observed in mammalian cells in culture.
Date of Publication: 1991
Number of Pages: 11
CAS Number*: 123-31-9
Format: PDF available for immediate download
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