Lithol rubine BK produced little irritation when tested, as the diluted material, on the skin of man and rabbits, and failed to induce skin sensitization in man. It was of low acute oral toxicity to rats and caused kidney damage on repeated oral administration. Studies involving multiple oral doses to pregnant rabbits and rats showed no adverse foetal effects. Fertility was decreased in the second generation of a limited three-generation oral rat study but no other reproductive effects were reported. There was no evidence of carcinogenicity in a limited dermal study in mice. No mutagenic activity was detected in Ames bacterial tests using pure samples.

Date of Publication: 1993

Number of Pages: 5

CAS Number*: 5281-04-9

Format: PDF available for immediate download

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