Propylparaben was an irritant to the skin of man. In volunteer studies, it exhibited a low sensitizing potential. The paraben esters as a generic class are rare skin sensitizers when applied to the intact skin of man. Application to damaged skin is a more common cause of sensitization. A methyl:ethyl:propyl mixture has been shown on oral administration to exacerbate pre-existing skin complaints. A low acute oral toxicity has been demonstrated for propylparaben in laboratory animals. Limited long-term oral studies in rats indicated a low toxicity and have generated no evidence of carcinogenic activity. In short-term oral studies forestomach changes were reported in rats, but not in hamsters. Propylparaben was not mutagenic in Ames bacterial tests. It has not been investigated in detail for reproductive effects.

Date of Publication: 1989

Number of Pages: 8

CAS Number*: 94-13-3


Format: PDF available for immediate download

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