Following public comments on their preliminary review on the risk assessment of genotoxic and carcinogenic substances (reported in Toxicology and Regulatory News 2008, 47(12), 209), the three Scientific Committees on Health and Environmental Risks (SCHER), Consumer Products (SCCP) and Emerging and Newly Identified Health Risks (SCENIHR) have now published their final report. The conclusions remain essentially unchanged from the earlier version with certain approaches being favoured for particular situations, in particular a linear extrapolation method (BMDL10 or T25) for cost-benefit analysis, and the MOE (margin of exposure) approach for risk communication. Each substance needs to be considered on a case-by-case basis, taking into account all available information on its toxicokinetics, toxicodynamics and possible mode of action.

[European Commission. Health and Consumer Protection DG. Risk assessment methodologies and approaches for genotoxic and carcinogenic substances. Adopted by the SCHER, SCCP and SCENIHR Committees on 13, 21 and 19 January 2009 respectively (available at] {179629}

The above item was taken from the March 2009 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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