With the implementation of REACH legislation (on the Registration, Evaluation, Authorisation and Restriction of Chemicals) in the EU, and the proposed revision to the Toxic Substances Control Act in the US, current risk assessment procedures are being subjected to major scrutiny. This navel gazing exercise is likely to result in a more routine application of read-across methodology (in which existing data on chemicals is used to predict the hazards of related substances with limited toxicity data), supported by (quantitative) structure activity relationship approaches (developments that should help reduce animal testing). The latest publication from ECETOC examines the use of (Q)SAR approaches and some of the available databases and software tools available to support the read-across process. It also considers how toxicogenomics and metabolomics can be used both to identify substances with a similar MOA (mode of action) and to predict the toxicological MOA of a substance for which data are lacking. Examples of the approaches that may be followed cover chemicals such as phthalates (notably dibutyl phthalate and di-2-ethylhexyl phthalate), oestrogens and skin sensitizers.

[European Centre for Ecotoxicology and Toxicology of Chemicals. High information content technologies in support of read-across in chemical risk assessment. Technical Report No. 109. The document, dated December 2010, can be obtained via http://www.ecetoc.org/publications on the ECETOC website.] {187112}

The above item was taken from the March 2011 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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