A task force of the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) has published guidance on how to classify carcinogens under the criteria for the globally harmonised system (GHS) of classification and labelling of chemicals. Concerns had been raised that the classifications were not sufficiently well defined and potentially allowed different conclusions to be drawn, and the guidance is intended to help in these areas by recommending the application of a series of questions during the evaluation of rodent studies. By way of illustration, five case studies are presented on the compounds thiamethoxam, melamine, dichlorvos, formaldehyde and Sudan I (McGregor D. et al., Critical Reviews in Toxicology 2010, 40, 245; http://dx.doi.org/10.3109/10408440903384717 – alternatively, the report can be obtained via http://www.ecetoc.org/articles on the ECETOC website). {184454}

The above item was taken from the April 2010 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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