Generally, chemical risk assessments focus on the potential issues presented by exposure to a single chemical substance in isolation. In reality, we are exposed to combinations of a vast array of chemicals on a day-to-day basis. With this in mind, EFSA has finalised its guidance on the risk assessment of mixtures. A comprehensive document, the guidance report discusses the scientific basis for mixtures risk assessment and approaches to assessing the (eco)toxicology of combinations of chemicals. A harmonised framework is provided, which considers both whole-mixture and component-based approaches. Specific advice is given on the formation and refinement of chemical assessment groups, the use of dose addition as a default assumption, and how to integrate evidence of chemical interactions. Case studies have also been included for illustrative purposes.

European Food Safety Authority (2019). Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals.


The above items were taken from the May 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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