T2 and HT2 toxins are produced by many species of Fusarium fungus that can infest crop plants. When ingested, T2 is rapidly hydrolysed to HT2, therefore EFSA evaluated the two mycotoxins together. It set an acute oral reference dose (ARfD) of 0.3 µg/kg bw for T2 and HT2, based on the potential for both chemicals to induce vomiting in mink. Following subchronic oral dosing of rats with T2, effects on the blood were critical, in particular reduced numbers of white blood cells; this was the basis for a tolerable daily intake (TDI) of 0.02 µg/kg bw established for both T2 and HT2 toxins (as well as their structurally-related metabolites and modified forms).

European Food Safety Authority (2017). Panel on Contaminants in the Food Chain (CONTAM). Appropriateness to set a group health based guidance value for T2 and HT2 toxin and its modified forms. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2017.4655/full

 

The above items were taken from the March 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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