EFSA has re-evaluated the tolerable daily intake (TDI) of phenol. A TDI of 1.5 mg/kg bw was set by EFSA’s predecessor, the Scientific Committee for Food (SCF), back in 1984, and several new studies have become available since. The benchmark dose level for a 10% reduction in maternal body weight gain (BMDL10) of 52 mg/kg bw/day, from a robust developmental toxicity study in orally-treated rats, was critical in deriving a new TDI of 0.5 mg/kg bw.

European Food Safety Authority. Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). Scientific opinion on the toxicological evaluation of phenol. EFSA Journal 2013, 11(4): 3189.

http://www.efsa.europa.eu/en/efsajournal/doc/3189.pdf

 

The above item was taken from the June 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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