Back in 2015, EFSA set a temporary tolerable daily intake (t-TDI) of 4 µg/kg bw for BPA, based on kidney effects seen in a 2‑generation study in mice. However, two immunotoxicity studies, not available for the 2015 evaluation, are suggestive of food intolerance and impaired immune responses in rats exposed perinatally to very low doses of BPA (in the μg/kg bw/day range). In response to a request from the Dutch Ministry of Health, Welfare and Sport, EFSA has assessed these data in the context of its t-TDI. The new evidence was said to “[add] to the indications of immunotoxicity of BPA in animals reported in previous reviews”, but was not considered sufficient to warrant a revision of the t‑TDI. EFSA noted that it will conduct a more thorough review of BPA in 2017.

European Food Safety Authority (2016). A statement on the developmental immunotoxicity of bisphenol A (BPA): answer to the question from the Dutch Ministry of Health, Welfare and Sport.

See for RIVM’s (2016) report [reported in our May 2016 issue of TRN].

See for an earlier EFSA comment [reported in our June 2016 issue of TRN].


The above items were taken from the December 2016 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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