EFSA’s Scientific Committee has issued a statement on the applicability of the margin of exposure approach for the safety assessment of genotoxic, carcinogenic impurities in substances added to food or feed. The Committee supports its 2005 opinion that the MOE approach can be applied to genotoxic carcinogens, whatever their origin. It reiterates that an MOE of 10,000 or higher would be of low concern from a public health point of view, when based on a benchmark dose level for a 10% increased incidence of tumours (BMDL10) from an animal study, and when overall uncertainties in interpretation have been taken into account.

European Food Safety Authority. Scientific Committee. Statement on the applicability of the Margin of Exposure approach for the safety assessment of impurities which are both genotoxic and carcinogenic in substances added to food/feed. EFSA Journal 2012, 10(3): 2578.



The above item was taken from the May 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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