Intended to facilitate the implementation of existing Agency guidance and to “improve the utility of risk assessment in the decision-making process”, the EPA has recently issued a draft framework for conducting human health risk assessments. This document covers the following key elements for conducting a risk assessment, including:

  • Planning and scoping, defining the intended purpose and context of the assessment.
  • Problem formulation, identifying the major factors that must be considered in the assessment, including the stressors, exposed populations and endpoints to be addressed.
  • Exposure and effects assessment, including hazard identification and dose-response relationship. Susceptible or highly exposed populations may be identified in this step.
  • Risk characterisation, providing risk managers with a useful set of conclusions about the assessed risk and judged by four principles: transparency, clarity, consistency and reasonableness.

US Environmental Protection Agency (EPA), Office of the Science Advisor, Risk Assessment Forum. Framework for human health risk assessment to inform decision making.
Draft, 12 July 2012.

http://www.epa.gov/raf/files/framework-document-7-13-12.pdf

 

The above item was taken from the September 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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