Two IRIS reviews have been finalised by the EPA, describing the scientific basis for the human health hazard and dose-response assessment of trimethylbenzenes (for which there was “inadequate information” to assess their carcinogenic potential but concerns about potential neurotoxicity) and of the non-cancer effects of inhaled ammonia.

A draft review of the military explosive, RDX, has also been released for public comment. While there are no data on the carcinogenicity of RDX in humans, results of studies in laboratory animals were considered to provide “suggestive evidence of carcinogenic potential”, based on increased incidences of lung and liver tumours.

US Environmental Protection Agency (EPA) (2016).

Toxicological review of trimethylbenzenes (CASRNs 25551-13-7, 95-63-6, 526-73-8, and 108-67-8). September 2016. EPA/635/R-16/161Fa. https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/1037tr.pdf

Toxicological review of ammonia. Non-cancer inhalation (CASRN 7664-41-7). September 2016. EPA/635/R-16/163Fa. https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0422tr.pdf

Toxicological review of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (CASRN 121-82-4). September 2016. EPA/635/R-16/208a. External review draft. http://ofmpub.epa.gov/eims/eimscomm.getfile?p_download_id=529180

 

The above items were taken from the November 2016 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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