The US NTP has recently finalised a report describing toxicology and carcinogenicity studies of senna, a plant product used as a stimulant laxative. According to the final report, no evidence of carcinogenic activity was seen in genetically modified mice (which are more responsive to carcinogens than conventional strains) fed senna in the diet at concentrations providing up to about 1400 mg/kg bw/day for 40 weeks. However, epithelial hyperplasia of the large intestine was seen in all mice at the top dose. The results of associated investigations undertaken by the NTP (notably a 5‑wk dietary study in mice and genotoxicity assays) are also presented in this final report, together with a review of pertinent toxicity and exposure information.

US National Toxicology Program. NTP Report on the Toxicology Study of Senna (CASRN 8013-11-4) in C57BL/6NTac Mice and Toxicology and Carcinogenesis Study of Senna in Genetically Modified C3B6.129F1/Tac-Trp53tm1Brd N12 Haploinsufficient Mice (Feed Studies).

Final dated April 2012

http://ntp.niehs.nih.gov/NTP/htdocs/GMM_rpts/GMM15_508.pdf

http://ntp.niehs.nih.gov/go/36138

The above item was taken from the June 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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