Chemicals may exert a range of effects on the immune system, but the methodology used to evaluate the safety implications of these biological changes may not always be consistent. In a step towards harmonizing current approaches to the immunotoxicity risk assessment process, the WHO has issued a finalised guidance document addressing the practical and theoretical considerations for evaluating immune system effects (including immunosuppression, immunostimulation and autoimmunity, as well as allergy). The guidance, which is intended to provide specialist immunotoxicological advice to the generalist risk assessor, presents six specific case studies on citral, halogenated platinum salts, lead, hexachlorobenzene, trichloroethylene and mercury.

World Health Organization (2012). Harmonization Project Document No. 10. Guidance for immunotoxicity risk assessment for chemicals.

http://www.who.int/ipcs/methods/harmonization/areas/guidance_immunotoxicity.pdf

 

The above item was taken from the April 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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