EFSA has considered the health risks associated with the presence of nickel in food and drinking water. Post-implantation foetal loss in treated rats was the critical effect used to derive a tolerable daily intake (TDI) of 2.8 µg/kg bw for long-term exposure. Additional concerns were raised for nickel-sensitised individuals, at risk of contact dermatitis following exposure. For these people, acute intakes of up to 0.11 µg/kg bw were “indicative of a low health concern”. Both acute and chronic levels of dietary intake were of concern for all age groups, and EFSA recommended that mechanistic work be done to assess the human relevance of the reproductive/developmental effects seen in exposed laboratory animals.

European Food Safety Authority. Panel on Contaminants in the Food Chain (CONTAM). Scientific opinion on the risks to public health related to the presence of nickel in food and drinking water. EFSA Journal 2015, 13(2), 4002. http://www.efsa.europa.eu/en/efsajournal/doc/4002.pdf

 

The above items were taken from the March 2015 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

 

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