An October 2016 meeting of the International Agency for Research on Cancer (IARC) discussed the carcinogenicity of the insecticide PCP, as well as that of aldrin, dieldrin, 2,4,6-trichlorophenol and 3,3’,4,4’-tetrachloroazobenzene (TCAB). PCP was “carcinogenic to humans” (Group 1), based on human evidence of an association with non-Hodgkin lymphoma and sufficient evidence of carcinogenicity in laboratory animals. There was also sufficient evidence in experimental animals to classify 2,4,6-trichlorophenol as “possibly carcinogenic to humans” (Group 2B), and aldrin and dieldrin as “probably carcinogenic to humans” (Group 2A). TCAB is not manufactured commercially, but is formed during the production and degradation of herbicides. It too was “probably carcinogenic to humans” (Group 2A), based on laboratory animal data.

These assessments will be published in detail in volume 117 of IARC’s Monographs on the Evaluation of Carcinogenic Risks to Humans.

Guyton KZ et al. (2016). Carcinogenicity of pentachlorophenol and some related compounds. Lancet Oncology. Article in press. 23 October 2016. http://www.thelancet.com/pdfs/journals/lanonc/PIIS1470-2045(16)30513-7.pdf
 

The above items were taken from the December 2016 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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