The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) has recently investigated possible classification criteria that will allow the identification of chemical eye hazards using only three animals (as opposed to current methods requiring between 6 and 18 animals). ICCVAM concluded that “using a classification criterion of one or more positive animals in a 3-animal test to identify chemicals and products that are eye hazards will maintain hazard classification equivalent to that provided by current testing procedures”, while using up to 50% to 83% fewer animals.

The Interagency Coordinating Committee on the Validation of Alternative Methods. ICCVAM Test Method Evaluation Report. Identifying Chemical Eye Hazards with Fewer Animals. 2012.

http://iccvam.niehs.nih.gov/docs/ocutox_docs/reducenum/TMER-all.pdf

 

The above item was taken from the November 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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