The International Life Sciences Institute in Europe (ILSI Europe) has published the conclusions of a 2008 workshop on the development and use of the MoE approach to address concerns arising from the presence of genotoxic carcinogens in food. Among the items discussed were the need for careful choice of cancer sites to be modelled and the human relevance of the tumours, the possibilities for combining data within and across studies, and the derivation of a suitable reference point (generally the lower confidence limit of the benchmark dose associated with a 10% change in response). However, it was noted that the MoE approach may not be suitable when there are too many uncertainties or weaknesses in the available data.

[Constable A. and Barlow S. Application of the margin of exposure approach to compounds in food which are both genotoxic and carcinogenic. October 2009. The document is accessible (at on the ILSI Europe website.] {184077}

As part of this MoE project, the ILSI Europe task force set up a new expert group to prepare case studies on 12 different chemicals: acrylamide, aflatoxin B1, benzo[a]pyrene, benzene, 1,3‑dichloro-2-propanol, ethyl carbamate, furan, leucomalachite green, 1-methylcyclopropene and its impurities, methyleugenol, PhIP and Sudan I. These reviews were published (in 2010) as Supplement 1 to volume 48 of the journal Food and Chemical Toxicology.

The above item was taken from the March 2010 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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