A recent issue of Mutation Research/Genetic Toxicology and Environmental Mutagenesis reports on the 8th International Symposium on Chromosome Aberrations in which speakers discussed how data from genotoxicity screening assays should be used in human risk assessments. According to the summary of the proceedings, “the field of regulatory toxicology currently is over-reliant on qualitative outcomes of in vitro hazard-screening tests, generally conducted at the maximum achievable exposures, and needs a more realistic approach that incorporates in vivo exposure levels and dose-response information” (Blakey D. et al., Mutation Research 2008, 657, 84; http://dx.doi.org/10.1016/j.mrgentox.2008.09.004). {180110}

The above item is taken from the January 2009 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).