ESAC, the Scientific Advisory Committee of the European Centre for the Validation of Alternative Methods (ECVAM), has endorsed the satisfactory performance of three in vitro skin irritation tests under the UN globally harmonised system (GHS) for the classification, labelling and packaging (CLP) of chemicals (implemented by Regulation (EC) No. 1272/2008). The CLP system uses a single skin irritant category with a cut-off score of 2.3 to distinguish between non-irritant and irritant substances, having shifted from the value of 2.0 used under the previous EU classification system. The three test methods, the EpiSkin, (modified) EpiDerm and SkinEthic RHE methods, are still considered by ESAC to be scientifically valid after taking this shift in the cut-off value into account, and updated accuracy values for all three tests have been issued. Further details (in a statement dated 9 April 2009) are available on the ECVAM website at (click on “news, events and meetings”). {181883}

The above item was taken from the June 2009 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).