In July 2016, OECD updated two TGs relating to reproductive/developmental toxicity, and adopted two novel in vitro TGs. The two updated ones, the reproduction/developmental toxicity screening test (TG 421) and the combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (TG 422), now also have endocrine disruptor-relevant endpoints. The ‘stably transfected human androgen receptor transcriptional activation assay for detection of androgenic agonist and antagonist activity of chemicals’ (TG 458) provides concentration-response data for substances with in vitro androgen receptor activity (i.e. potential endocrine-disrupting properties). The in vitro human Cell Line Activation Test (h-CLAT) (TG 442E) quantifies changes in the expression of cell surface markers associated with the process of activation of monocytes and dendritic cells in human leukaemia cells following exposure to sensitisers. The h-CLAT constitutes the third step in the adverse outcome pathway (AOP) for skin sensitisation.

Organization for Economic Co-operation and Development (2016). Guidelines for the testing of chemicals. Available via http://www.oecd-ilibrary.org/environment/oecd-guidelines-for-the-testing-of-chemicals-section-4-health-effects_20745788

 

The above items were taken from the October 2016 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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