In July 2016, OECD updated two TGs relating to reproductive/developmental toxicity, and adopted two novel in vitro TGs. The two updated ones, the reproduction/developmental toxicity screening test (TG 421) and the combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (TG 422), now also have endocrine disruptor-relevant endpoints. The ‘stably transfected human androgen receptor transcriptional activation assay for detection of androgenic agonist and antagonist activity of chemicals’ (TG 458) provides concentration-response data for substances with in vitro androgen receptor activity (i.e. potential endocrine-disrupting properties). The in vitro human Cell Line Activation Test (h-CLAT) (TG 442E) quantifies changes in the expression of cell surface markers associated with the process of activation of monocytes and dendritic cells in human leukaemia cells following exposure to sensitisers. The h-CLAT constitutes the third step in the adverse outcome pathway (AOP) for skin sensitisation.

Organization for Economic Co-operation and Development (2016). Guidelines for the testing of chemicals. Available via


The above items were taken from the October 2016 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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