The NTP has finalised its technical report on the toxicology (including genotoxicity) and carcinogenicity of PCBTF.

Inhalation exposure of male and female mice to PCBTF for 2 years caused “clear evidence of carcinogenicity”, based on increased incidences of adenoma, carcinoma and blastoma in the liver. There was “some evidence of carcinogenicity” in male and female rats, with the thyroid gland the primary site of tumour formation. Exposure also caused non‑neoplastic lesions in the lungs and liver of male and female rats and mice, as well as the uterus of female rats, the forestomach of male and female mice, and the larynx of male mice.

US National Toxicology Program (2018). Technical Report on the toxicology and carcinogenesis studies of p-chloro-α,α,α-trifluorotoluene in Sprague Dawley rats (Hsd:Sprague Dawley SD) and B6C3F1/N mice (inhalation studies). NTP TR 594. June 2018. https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr594_508.pdf

 

The above items were taken from the August 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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