The NTP has issued the final version of its technical report on the toxicology (including genotoxicity) and carcinogenicity of green tea extract. The 2-year gavage studies indicated “no evidence of carcinogenic activity” in rats or mice of either sex. This marked a change from the earlier, draft report, which suggested “equivocal evidence” of carcinogenicity in female mice.

A final report on the toxicity studies of α-pinene, administered by whole-body inhalation to rats and mice (10/sex/species/group) at concentrations of 0, 25, 50, 100, 200 or 400 ppm for 3 months, has also been released. All exposed animals survived to the end of the study, aside from 6 female rats in the high-concentration group. There were treatment-related effects on the liver, urinary system and male reproductive system. A lowest-observed-effect level (LOEL) of 25 ppm was established for male and female rats based on effects in the kidneys of the males and liver of the females. Adverse effects on the urinary bladder in mice were reported at a LOEL of 100 ppm.

US National Toxicology Program (2016).

Technical report on the toxicology studies of green tea extract in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of green tea extract in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies). NTP TR 585. April 2016.

Technical report on the toxicity studies of α-pinene (CAS No. 80-56-8) administered by inhalation to F344/N rats and B6C3F1/N mice. NTP TOX-81. May 2016.


The above items were taken from the June 2016 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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