In line with the classification system established in 1983 to evaluate cancer bioassays, the NTP has proposed using the same categories (known as “levels of evidence” statements) to also describe its non-cancer study findings. These levels are “clear evidence”, “some evidence”, “equivocal evidence” or “no evidence”, and will be used in the near future to describe the findings from reproductive, developmental and immunotoxicity studies. A fifth and final category describes an “inadequate study”. This proposal will enable NTP scientists to use a set of standardised criteria for classifying the relative strength of experimental outcomes in both cancer and non-cancer studies.

[US National Toxicology Program. NTP unveils non-cancer evaluation criteria. Available at (web-page last updated 6 March 2009). An article published in the peer-reviewed literature further describes this proposal (Weinhold B., Environmental Health Perspectives 2009, 117, A113).] {181287}

The above item was taken from the April 2009 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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