Finalised guidance released in August 2011 by OECD relates to the development of acute reference concentrations (levels at which a chemical is unlikely to cause serious health effects following inhalation exposures of up to 24 hours). Example assessments are presented for ethylene oxide, hexachlorocyclopentadiene, hydrogen sulphide and phosgene. OECD guidance notes have also been recently finalised on dermal absorption studies, in which recommendations are given on the interpretation of in vitro and in vivo data, and approaches outlined for estimating absorption in the absence of specific studies.

[Organisation for Economic Co-operation and Development. Guidance document for the derivation of an acute reference concentration (ARfC). ENV/JM/MONO(2011)33. Series on Testing and Assessment No. 153. Dated 19 August 2011 (available on the OECD website at Guidance notes on dermal absorption. ENV/JM/MONO(2011)36. Series on Testing and Assessment No. 156. Dated 18 August 2011 (available at] {182827; 186673}

The above item was taken from the October 2011 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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