The OECD has issued the second edition of its guidance on the grouping of closely-related chemicals for data-gap filling by read-across, trend analysis and (quantitative) structure-activity relationships ((Q)SARs). The report elaborates on the analogue and category approaches for grouping chemicals, discusses how mode of action/adverse outcome pathway and bioprofiling information can be used to form and justify chemical categories, and provides guidance on specific types of category approaches (e.g. for complex substances of unknown or variable composition (UVCBs) and metals).

Organisation for Economic Co-operation and Development (2014). Guidance on grouping of chemicals, second edition. Series on Testing & Assessment No. 194. ENV/JM/MONO(2014)4. 14 April 2014.

The above items were taken from the June 2014 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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