A new test guideline (TG) for the in vivo mammalian alkaline comet assay (TG 489) has now been adopted by OECD. The assay is used to determine the potential for a chemical to damage the DNA.

The following revised TGs have also recently been adopted:

  • TG 431 (in vitro skin corrosion; reconstructed human epidermis (RhE) test method)
  • TG 473 (in vitro mammalian chromosomal aberration test)
  • TG 474 (mammalian erythrocyte micronucleus test)
  • TG 475 (mammalian bone marrow chromosomal aberration test)
  • TG 487 (in vitro mammalian cell micronucleus test)

In addition, draft performance-based test guidelines have been released on:

  • the human cytochrome P450 (CYP) n-fold induction in vitro test method (to inform on mode of action)
  • human recombinant estrogen receptor (hrER) in vitro assays (to detect chemicals with ER binding affinity)

Organisation for Economic Co-operation and Development (2014). Guidelines for the testing of chemicals.

Adopted TGs. http://www.oecd-ilibrary.org/environment/oecd-guidelines-for-the-testing-of-chemicals-section-4-health-effects_20745788

Draft TGs. http://www.oecd.org/env/ehs/testing/section4healtheffects.htm


The above items were taken from the November 2014 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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