Consumer health risk assessment of two major constituents of e-cigarette formulations


A major e-cigarette manufacturer.


Most electronic cigarettes contain high concentrations of select organic chemicals as the main constituents of the liquid formulation. Bibra was asked to carry out health risk assessments relating to two key constituents of an e‑cigarette formulation on the basis that they might be inhaled by the consumer (along with nicotine and other additives).

Project Goals

To provide the client with high-quality risk assessments for two major constituents in an e-liquid formulation.


We searched for, collated and critically assessed the hazard data and key existing HCVs for each constituent, focusing on the inhalation route of exposure. Existing Expert Group reports and comprehensive reviews were used as the basis as far as possible for these well-studied chemicals.

Using a specific e-cigarette vaping scenario as detailed by the client, we conducted a comprehensive risk assessment of the systemic and local toxicity of the two constituents.

Project Outcome

Bibra was able to conclude that the estimated exposures to the formulation constituents were unlikely to pose any significant systemic risks to consumer health, based on bibra-derived HCVs (i.e. application of suitable uncertainty/safety factors to appropriate Points of Departure from the underlying toxicological datasets). A more critical consideration was the potential for irritation of the respiratory tract at the high concentrations in the vapour from the device. It was considered that the possibility for local irritation to occur could not be ruled out. However, bibra described various factors that mitigated this risk.

Project Leader

Daniel Threlfall
Pete Watts
Richard Young



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