Health Canada

Categorization under the Canadian Environmental Protection Act (CEPA) 1999

Providing advice and critical comment on “Categorization of Organic Substances on the Domestic Substances List (DSL) for Inherent Toxicity to Humans: Proposed Initial Approach and Criteria” based on a processing of 100 compounds.


Carcinogenicity and genotoxicity and CEPA: possible next steps

To consider how a categorization scheme or a prioritization process might be developed to reduce the number of compounds on the DSL that needed subsequent additional detailed phases of assessment based on an initial ranking as either carcinogens or genotoxins.


Polymers and CEPA: possible next steps

A consideration of how around 200 polymers might be prioritized for toxicity categorization under CEPA 1999.


The exposure response tool and some other CEPA issues

Consideration of the most cost-effective means to introduce a measure of dose-response for substances already identified as a problem by the Categorization process.


UVCBs and CEPA 1999

A consideration of the compositional issues related to a large list of UVCBs (Chemical Substances of Unknown or Variable Composition, Complex Reaction Products and Biological Materials) and how these might be handled under CEPA 1999.


Thinking piece on petroleum UVCBs

Consideration of how the objectives outlined in CEPA 1999 might be achieved with respect to the petroleum products on the DSL.


Toxicity Profiles

Preparation of around 75 Toxicity Profiles for a subset of compounds (High or Intermediate Hazard, Greatest Potential for Human Exposure) on the “Maximal List“ of the DSL.


Comprehensive Hazard Reviews

Preparation of sections 8 (“Kinetics and Metabolism”), 9 (“Mammalian Toxicology”) and 10 (“Effects on Humans”) of Supporting Documentation for 19 Priority Substances under the CEPA 1999.


Section 75 succinct summaries

Identification and summary of the main toxicological concerns that gave rise to the regulatory restrictions on 20 compounds banned or substantially restricted in OECD countries or elsewhere around the world.


Screening assessments

Peer review of ten draft Screening Health Assessment Reports prepared by Health Canada.


Robust toxicity summaries

Preparation of robust summaries on perfluorooctylsulfonyl, perfluorobutylsulfonyl and perfluoroalkyl compounds.


State of Science (SOS) reports

Preparation of an SOS report from an existing generic SOS, together with updating from the published literature. Peer review of the draft of another SOS report.


Fact sheets

Identification, summary and critical evaluation of the information on human, laboratory animal and in vitro studies of the toxic effects of 21 substances.


“Insufficient to conclude”

Peer review of a “Follow-up report on a PSL1 substance for which data were insufficient to conclude whether the substance was “Toxic” to human health: chlorinated paraffins”.


Peer review of hazard reports

Peer review of 33 hazard reports prepared by Health Canada.



Information and advice on the genotoxicity profile of hexachloroethane.


Peer consultation on genotoxicity

A contribution within a peer consultation on genotoxicity for categorization of “Inherent Toxicity” to humans.



Participation in a workshop on (quantitative) structure activity relationships (Q)SAR models and subsequent preliminary analyses of a range of analogue identification tools.


No-effect levels

Analysis of the variations between effect levels in comparable sub-chronic and chronic studies to determine what uncertainty factor should be applied in the development of tolerable intakes for “less than chronic” studies.


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