At the end of last year, ICCVAM recommended that the Isolated Chicken Eye (ICE) and Bovine Corneal Opacity and Permeability (BCOP) test methods may be used (where appropriate and with certain limitations) to determine hazards to the eye as part of a weight-of-evidence approach (see Toxicology and Regulatory News 2008, 47(1), 10). It was also recommended that substances testing positive with these methods should be classified as ocular corrosives or severe irritants without further testing in animals. US federal regulatory agencies (including the FDA and EPA) have now accepted these recommendations, a decision that evidently makes these assays the “first scientifically valid alternative methods to gain regulatory acceptance for ocular safety testing”.

[US National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) and Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). In vitro test methods for detecting ocular corrosives and severe irritants. Visit with link to National Institute of Environmental Health Sciences (NIEHS) Press Release dated 23 June 2008 giving background to the regulatory decision.] {173098}

The above item is taken from the August 2008 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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