Until comparatively recently, the traditional risk assessment process for dermal allergens aimed at hazard identification only, and resulted in the classification of chemicals either as sensitizers or non-sensitizers. Since then, things have moved on, with the development of more quantitative approaches, including a recent proposal put forward by the Research Institute for Fragrance Materials (RIFM) and the International Fragrance Association (IFRA). RIVM has now published a report reviewing this whole issue, and the RIFM/IFRA proposal in particular. Overall, RIVM viewed the RIFM/IFRA proposal favourably, although some modifications were suggested. Various specific recommendations were made by RIVM as a result of a case study with citral, in particular the importance of considering all sources of exposure. It was also recommended that “more transparent guidance is given for general risk assessors in the (weight of evidence) derivation of a threshold” (No Expected Sensitization Induction Level or NESIL).

[Ter Burg W. et al. (2010). Dutch National Institute for Public Health and the Environment (RIVM). Observations on the methodology for quantitative risk assessment of dermal allergens. RIVM Report 320015003/2010. Available at http://www.rivm.nl/bibliotheek/rapporten/320015003.pdf on the RIVM website.] {186781}

The above item was taken from the January 2011 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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