Since the ban of ephedrine in food supplements due to its possible adverse effects on human health, the structural analogue synephrine has been increasingly used as a substitute in supplements used for weight loss or by athletes. Currently there is no legislation in the Netherlands that limits the amount of synephrine in food supplements, and as such, RIVM has conducted a risk assessment of the substance. It found that the toxicological data on synephrine are limited, especially with regards to long-term health effects, and therefore it was not possible to derive a health-based guidance value.

Dutch National Institute for Public Health and the Environment (RIVM) (2017). Risk assessment of synephrine. RIVM Report 2017-0069.


The above items were taken from the May 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

News Home Guest Write For Us? Contact Us