The threshold of toxicological concern (TTC) concept centres on the idea that there is a level of exposure for chemical substances below which there is no appreciable risk to human health. This concept may be used instead of substance-specific toxicological information in cases where humans are exposed to very low, or negligible, levels of a chemical about which little is known. The principles, concept and historical developments behind the TTC approach are described in a recent report produced by the Danish EPA, which also evaluates the benefits, limitations and uncertainties associated with this approach. Current and future applications are discussed, including the applicability of the TTC concept within REACH (the European legislation on the Registration, Evaluation, Authorisation and Restriction of Chemicals), and its use in the risk assessment of low-level impurities in consumer products, food and the environment. The Danish EPA suggests that TTC considerations may help set priorities for further research as efforts can be directed towards those chemicals for which human exposure exceeds the relevant TTC value.

[Nielsen E. and Larsen J.C. (2011). The Threshold of Toxicological Concern (TTC) concept: Development and regulatory applications. Danish Ministry of the Environment, Environmental Protection Agency. Environmental Project No. 1359 2011. This report can be downloaded at online.] {187584}

The above item was taken from the June 2011 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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