Toxicity Profile for Tris(2-chloroethyl) phosphate (1994)

Abstract

Tris(2-chloroethyl) phosphate (TCEP) exhibited moderate acute toxicity by the oral route in rodents and was of low acute toxicity in rabbits treated dermally. In studies on rabbits, TCEP was minimally irritating to the eyes and, at most, slightly irritating to the skin. The principal sites of toxic attack in rats and mice, given repeated oral doses, were the liver, kidney, brain and male reproductive system. In rodents treated orally or by inhalation reproductive success was impaired, sperm abnormalities were induced and there were embryo deaths (indicative of dominant lethal mutations). There was some evidence of chromosomal damage in hamsters given a single intraperitoneal injection and in mammalian cells in culture. Other assays (for transformation) in mammalian cells have also given evidence of genotoxicity, although negative results have in general been obtained in other screening assays, including the Ames bacterial test. In oral studies TCEP was shown to be a kidney carcinogen producing malignant and benign tumours in mice and benign tumours in rats.