Our work

Our food supply needs to be protected from the harmful action of organisms like fungi and insects. The formulations designed to achieve this are not perfect and it is important to assess the risks to humans, other non-target animals, or to the environment.

A high-quality assessment of the toxicology of a plant protection product is a cornerstone of any submission for approval. Our extensive experience in identifying, interpreting and summarising toxicological data makes us an ideal partner for this aspect of your PPPR submissions.

Literature searching

Pesticide active substances are approved in the EU for a defined period of up to 15 years. As part of the renewal process, companies are required to submit data published since the previous evaluation. We have years of experience in performing tailored, sector-specific literature searches. Our skills in this area make us a valuable partner in the preparation of plant protection product authorisation and renewal dossiers.

Exposure Estimation

Once a chemical’s toxicological hazards have been characterised, it is crucial to understand what the potential human exposure might be. This is always difficult, particularly so for plant protection products, where very different tribes might be at risk (e.g. professional users, bystanders and even inadvertently-exposed children).

We always treat exposure estimation as a collaborative process, guiding our clients to identify the information necessary for a robust health risk assessment. We are, though, familiar with many of the key software tools for exposure estimation, including ECHA’s Chesar, EasyTRA, BEAT, EUSES and ConsExpo, as well as the key guidance relating to modelling of biocide exposures.

Helpful link

Regulation (EC) 1107/2009 concerning the placing of plant protection products on the market

Some of our case studies in this area

Evaluation of the endocrine-disrupting potential of a plant protection product

Case study

The Plant Protection Products Regulation (EC) No 1107/2009 is amended by Regulation (EU) 2018/605, requiring that information on the potential endocrine-disrupting properties of such products must be collated and evaluated. The European Chemicals Agency (ECHA) and the European Food Safety Authority (EFSA) have published “Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009”, detailing the performance of such hazard identification, together with an Excel spreadsheet to be used as a template for gathering the necessary information on “human and animal health” and “non-target organisms”.

Literature Review Report in support of a plant protection product active substance regulatory submission

Case study

The approval or re-registration of pesticide active substances (Plant Protection Products) under Regulation (EC) No 1107/2009 Article 8(5) requires applicants to submit dossiers containing scientific peer-reviewed open literature on the active substance and its relevant metabolites and impurities, dealing with side-effects on human health, the environment and non-target species, published within ten years of the date of dossier submission.

Get in touch

Please read our Privacy Policy here

*mandatory fields

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Contact us