Our work

Safety benchmarks are an essential part of assessing the risk chemicals pose to human health. At bibra, we specialise in identifying and deriving these benchmarks. They represent the estimated maximum exposure, generally qualified by route (through skin contact, inhalation, or ingestion), that will pose no significant threat. Our approach involves extensively analysing evidence from occupational and epidemiological studies and laboratory animal assays. When available, we also incorporate data on the chemical’s absorption, distribution, metabolism, and excretion (ADME). By combining these data sources, bibra ensures accurate and scientifically robust safety benchmarks that meet our clients’ needs.

Existing Safety Benchmarks

Expert Groups both independent and industry-led, will often establish these safe limits as part of their reviews of chemical substances. They use various terminologies like Acceptable Daily Intake (ADI), Reference Dose (RfD), and Maximum Residue Limit (MRL) and more surprisingly, different quantitative views on how to account for uncertainty. Where a benchmark is set by the authoritative body in a particular industry sector, this becomes an important influence on a bibra risk assessment for clients in that same business area. With bibra's expertise, companies can confidently align their products and practices with the highest safety standards.

Bibra’s Role in Identifying Safety Benchmarks

Our in-house database, TRACE, is ideal for the speedy identification of existing safety benchmarks, and provides a reliable and efficient method of data searching and retrieval. Our scientists have extensive experience of assessing and recording safety benchmarks from a range of sources, comparing the values, and discussing the approach taken in their derivation. This is particularly beneficial to our clients when existing benchmarks from Expert Groups need further clarification or supplementation.

Deriving a new Safety Benchmark

There may be instances where no appropriate Expert Group assessments can be identified, or existing benchmarks don't fit specific scenarios. In such cases, bibra steps in to derive and develop safety benchmarks tailored to the client’s needs. This process will usually involve identifying a critical data point from a laboratory animal experiment, and adjusting to account for the likely differences in how humans and other species (usually a rodent) respond to chemicals in general or (much more rarely) to that specific test chemical. This adjustment is made in line with sector-specific guidance to ensure the most accurate and applicable benchmark for our clients.

Bibra’s Expertise Across Industries

Our team has an unrivalled level of expertise in deriving safety benchmarks in chemical risk assessments. Our work spans various sectors – from pharmaceuticals to consumer goods. We are particularly skilled in addressing complex challenges in industries like medical devices, chemicals (particularly toxicity issues generated by REACH), electronic cigarettes, food additives and materials in contact with food.

Our comprehensive approach ensures that businesses across these sectors meet safety standards and regulatory requirements effectively. For more information on how bibra can help you with safety benchmarks, contact us today.

Some of our case studies in this area

ISO 18562 evaluation of a medical device in contact with the breathing gas pathway

Case study

As part of a large programme of work in evaluating the safety of a new endotracheal tube device, bibra was asked to evaluate the health risks posed by exposure to potentially hazardous substances that may be transferred to the patient via the gas stream during device use.

PDE for a leachable in an intravenous pharmaceutical

Case study

ICH defines a Permitted Daily Exposure (PDE) as a pharmaceutically acceptable intake “protective of public health for all patient populations” and provides specific guidance on the derivation of PDEs for threshold toxins identified as residual solvents (Q3C guideline) and elemental impurities (Q3D guideline) in pharmaceuticals.

Derivation of a Tolerable Daily Intake (TDI) for a chemical in Food Contact Materials (FCMs)

Case study

Food-Contact Materials (FCMs) encompass all materials and articles that come into contact with food as it is produced, packaged, stored and consumed. Experts from the European Food Safety Authority (EFSA) have stated that the safety of FCMs must be evaluated to ensure that their potential transfer to foods would not have any adverse effects on consumers . Under EU regulation (EC) 1935/2004, FCMs must not transfer their components into the foods in unacceptable quantities.

Derivation of an intravenous PDE for a common leachable

Case study

Chemicals that leach into drug products from processing or manufacturing equipment, drug delivery systems and/or packaging may pose a health risk to patients.

Get in touch

Please read our Privacy Policy here

*mandatory fields

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Contact us