What we do

Our scientists know that a robust risk assessment relies upon quality data. We are experienced searchers of the major toxicity databases, databanks and internet. In addition, our in-house database, TRACE, gives us valuable access to Expert Group and primary reports that are not reliably identified via searches the usual range of data sources. All of the documents on TRACE have been selected and indexed by our expert toxicologists, ensuring chemical-specific, reliable and highly efficient retrieval of relevant information. This unique combination is a key part of nearly every project we work on, and the details of our search methods are described in resulting reports with a high degree of transparency.

Search terms

We have years of experience in selecting and using search terms likely to be relevant to a client’s areas of interest, potentially saving a great deal of time that would otherwise be spent trawling through irrelevant hits. Searches of TRACE, in particular, can be focused with just a few clicks, providing a much more relevant output than comparable external databases.


Data-poor target compounds may have data-rich structural analogues or metabolites/ precursors. With a robust read-across approach based on surrogate data, the use of Threshold of Toxicological Concern (TTC)-based risk assessments or laboratory testing on the target compound can be avoided. Our extensive expertise in this area allows us to assess and justify the relevance of read-across compounds in providing toxicological insights. We routinely run parallel literature searches on target and read-across compounds and provide a comprehensive data matrix containing the resultant bibliographic details.


When it comes to searching for toxicity data, we are ideally placed to help. For decades, we have performed searches of a tried-and-tested series of external databases (including some subscription-only packages) using searching strategies tailored to a sector. Our literature-searching skills (along with our extensive evaluation expertise) are invaluable in conducting full reviews for any chemical substance.


In addition to performing literature searches for use in health risk assessments, we offer a “current awareness”, Selective Dissemination of Information (SDI) service. We carry out regular searches, of an agreed range of data sources, for new toxicity data on substances of commercial or research importance to specific clients, at requested intervals. This ensures that companies are always up to date on their key substances.

Some of our case studies in this area

Literature monitoring for an industry group

Case study

The scientific literature can provide an early indicator of potential changes in the regulatory status of chemical substances. Organisations representing different chemical sectors may therefore provide services to their members that keep them up to date with the latest relevant publications on the toxicology of their chemicals in humans and other animals, as well as their persistence in the environment.

Derivation of an intravenous PDE for a common leachable

Case study

Chemicals that leach into drug products from processing or manufacturing equipment, drug delivery systems and/or packaging may pose a health risk to patients.

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