Toxicity Profile for Toluidine Red (1996)
Abstract
Toluidine Red may produce skin sensitization reactions in man and can be irritating to the skin. It was a mild eye irritant in rabbits. In rats, the acute oral toxicity was low. Repeated oral administration produced effects on the blood, spleen, kidney and liver of rats and mice, and the ovaries of mice. An Ames bacterial test has given evidence of weak mutagenicity, but no chromosome effects were seen in mammalian cells in culture. Long-term dietary administration resulted in the development of tumours of the liver, skin, adrenals and Zymbal gland in rats and kidney and thyroid tumours in mice.
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