Triethyl citrate (1998)
Abstract
Triethyl citrate was not an irritant to the skin of humans and laboratory animals. In dilute form, it showed no sensitizing potential in humans. Acute toxicity was low by the oral, dermal and inhalation routes in laboratory animals. Single oral treatment caused kidney damage in rats, and central nervous system (CNS) effects were seen following oral or injection administration to various species of laboratory animal. In limited studies, repeated oral doses were tolerated by rats but caused liver damage in dogs and CNS effects in cats. Rats exposed repeatedly to the vapour showed lung damage. Triethyl citrate was non-carcinogenic when given orally to rats in a limited study and was non-mutagenic in an Ames bacterial test and in yeast. Its hydrolysis products are citric acid and ethanol.
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