Lead naphthenate (1999)
Abstract
Occupational exposure to lead naphthenate has been tentatively linked with systemic effects (including central nervous system disorders) typical of lead intoxication. Multiple skin applications of a dilute preparation did not induce skin sensitization or irritation in volunteers. Lead naphthenate had a low acute oral toxicity in rats. Repeated skin application has caused local irritation and increased testis weight in rats and kidney damage in mice. A limited study where lead naphthenate was applied repeatedly to the skin of mice has given equivocal evidence of carcinogenicity. Lead naphthenate was not mutagenic in an Ames bacterial assay.
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