Ethyl methylphenylglycidate (2001)
Abstract
Ethyl methylphenylglycidate (EMPG) irritated the skin of some individuals. Skin sensitization was not induced in volunteers given repeated applications of a dilute solution. EMPG was of low acute oral toxicity in rodents. Long-term feeding studies generated no clear evidence of carcinogenicity, although treated male rats had increased incidences of cellular changes in the liver, pancreas, adrenal glands and lymph nodes. In shorter feeding studies in rats, various organ weight changes, slight paralysis of the hind limbs, together with associate nerve degeneration, and marked wasting of the testes were seen. Chromosome damage occurred in mammalian cells in culture but not in the bone marrow cells of mice given a single intraperitoneal injection. There was no evidence of mutagenicity in bacterial assays (including Ames tests) although a weak mutagenic effect was seen in the fruit fly.
Toxicity Profiles are comprehensive, yet concise, monographs on the hazard potential of individual chemicals. They are written by scientists specially trained in the evaluation of toxicity data and are prepared principally from primary information sources. To see the full list of nearly 500 Toxicity Profiles currently available, please click here. Profiles can be obtained by contacting our help desk (e-mail document@bibratoxadvice.co.uk) or by completing the enquiry form on the Contact Us page.
Copyright © 2001 BIBRA Information Services Ltd