Ethyl vanillin (1988)
Abstract
In a volunteer study, ethyl vanillin (EV) demonstrated no sensitizing potential but was a skin irritant. Acute oral toxicity was low by the oral route in rats and rabbits although a high oral dose caused central nervous system effects and coma in rats and rabbits. In rats and rabbits treated by multiple oral dosing, cellular changes were seen in the heart, lungs, liver and kidneys. A limited long-term feeding study generated no evidence of carcinogenicity. EV did not cause structural damage to mammalian chromosomes in vivo or in vitro. It was non-mutagenic in the bacterial Ames test and did not induce heritable mutations in fruit flies.
Toxicity Profiles are comprehensive, yet concise, monographs on the hazard potential of individual chemicals. They are written by scientists specially trained in the evaluation of toxicity data and are prepared principally from primary information sources. To see the full list of nearly 500 Toxicity Profiles currently available, please click here. Profiles can be obtained by contacting our help desk (e-mail document@bibratoxadvice.co.uk) or by completing the enquiry form on the Contact Us page.
Copyright © 1988 BIBRA Information Services Ltd