Toxicity Profile for Methylene bis(thiocyanate) (1996)
Abstract
In man, methylene bis(thiocyanate) (MBT) was a skin irritant and possibly a skin sensitizer. When tested dermally in guinea-pigs, a biocide containing the thiocyanate displayed irritancy and sensitizing potential. A high acute oral toxicity was indicated in rats treated with MBT. In 13-wk oral studies, there were effects on the nasal cavity, windpipe and (fore)stomach of rats and mice. The blood and sperm of rats were also affected. There was no evidence of mutagenicity in a limited Ames bacterial test, or of chromosomal damage in rats treated orally.
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