Toxicity Profile for Benzotriazole (1995)
Abstract
Benzotriazole was a skin irritant in guinea-pigs and a severe eye irritant in rabbits. Allergic dermatitis has occurred in a small number of workers although guinea-pig studies indicated only a weak sensitizing potential. In acute studies, benzotriazole was of moderate oral toxicity to rats, mice and guinea-pigs, and of low dermal toxicity to rabbits. Single inhalation exposure was of moderate to high toxicity in rats affecting the windpipe and lungs. A limited report indicated that benzotriazole caused foetal deaths and ovary changes in rats. Cellular effects in a range of organs occurred in long-term oral studies in rats and mice although there was inconclusive evidence of carcinogenicity. Benzotriazole was mutagenic in bacterial tests including the Ames.
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