Toxicity Profile for 2,4,6-Trichlorophenol (1991)


2,4,6-Trichlorophenol was irritant to the skin and eyes of rabbits and was of low acute oral toxicity in rats. In rodents, repeated oral exposure caused liver damage and had effects on the spleen and bone marrow. Exposure of rats, via the drinking water, during pregnancy, decreased litter size and increased the number of stillbirths. In feeding studies, there was an increase in the incidence of liver tumours in mice and of leukaemia in rats. 2,4,6-Trichlorophenol was mutagenic to mice following intraperitoneal injection and caused chromosome damage and mutagenic effects in mammalian cells in culture. No mutagenicity was demonstrated in Ames bacterial tests, although there was evidence of DNA damage in bacteria.

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