Toxicity Profile for Dichlofluanid (1990)

Abstract

Dichlofluanid caused slight skin irritation and moderate eye irritation in rabbits. It was of low to moderate acute oral and dermal toxicity in laboratory animals, with oral exposure inducing various effects including central nervous system disturbances and damage to the kidney, liver and gastro-intestinal tract. Prolonged oral administration produced changes in the liver, kidneys, spleen, testes, adrenals, bones and lungs, affected thyroid function, and altered blood composition in rodents and dogs. Foetal toxicity and malformations occurred when pregnant rats and rabbits were fed maternally toxic doses. No evidence of carcinogenicity was seen in limited long-term feeding studies in rodents. Genotoxicity tests indicated a slight dominant lethal effect in mice treated orally but no chromosomal damage was reported in hamsters or mice fed dichlofluanid. Bacterial assays (including Ames tests) gave evidence of mutagenicity and DNA damage.